Pipeline

Zelluna’s pipeline assets target a blend of antigens that are either clinically or preclinically validated and expressed across a broad range of solid tumour indications, providing high potential for patient impact and a huge market opportunity.

  • MAGE-A4 and PRAME are clinically validated TCR targets in solid cancers: a MAGE-A4-targeting TCR therapy has received market approval, and a PRAME-targeting TCR therapy is in a Phase 3 registration trial.
  • KKLC-1 is a preclinically validated solid cancer target.

Zelluna’s positive regulatory interactions and plug-in manufacturing process apply across the entire pipeline, helping to de-risk the development path for all programmes.

Zelluna TCR-NK pipeline chart showing ZI-MA4-1 (MAGE-A4), ZI-KL1-1 (KK-LC-1) and ZI-PR-1 (PRAME) and their stage of development